![]() ![]() While Satterthwaite may seem to you to be flawed or outdated, if the FDA want that for bioequivalence then that's what you give them. Having said that, if you're doing pharms work, then follow the path required by the FDA. There are also other possible places you'll find by searching on "STAT" and "LIST" or "Discussion". I know that University of Georgia runs a series of discussion list servers where you can read (listen) to the opinions of many statistically dexterous minds and I think that is where I'd go if I wanted an opinion based on statistical theory, and not on utility of a given software package.Ī search for "stat-l" and "uga" will find you the address for the Georgia discussion list server. Faced with a similar dilemna, I would be looking for a stats discussion group. I think that is where your question belongs. The default (and only, prior to Version 26) method for denominator df calculation in MIXED is Satterthwaites approximate method, since the precise df arent generally known for many mixed models. There are some exceptions, especially in the Stat area, but the selection of method and interpretation of results really belongs in a general statistical discussion group. I see it as an extension of the software manual that tells you how to use the software, not why a given model is selected. This function allows the calculation of the correct degrees of freedom based on the specified design structure. Fill in the Numerator degrees of freedom with 3 and the Denominator degrees of freedom with 246. The SAS forums should concentrate on the use of SAS to produce an outcome, and the areas in which the SAS procedure is not delivering the required result. The available techniques for doing so, however, 'trick' the algorithm the packages uses for calculating denominator degrees of freedom, (almost always) leading to inflated p-values. Select Graph > Probability Distribution Plot > View Probability. I'm not convinced that this belongs in this discussion group. ![]()
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